Monday, October 27, 2008
Exercise and Neurogenesis in the Mouse Brain
More information once again that exercise may help your brain function better! I know it is a fury critter study, but there are not many that are going to sign up for brain damage as part of a study (unless they already have brain damage).
Be sure to check the other blog entries such as
Be smart exercise your heart:exercise and cognition
Movement and brain deterioration-new study
Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain
Andrew S. Naylor*,†,‡, Cecilia Bull*,‡, Marie K. L. Nilsson§, Changlian Zhu*, Thomas Björk-Eriksson¶,‖, Peter S. Eriksson*, Klas Blomgren*,**,††, and H. Georg Kuhn*,
Cranial radiation therapy is commonly used in the treatment of childhood cancers. It is associated with cognitive impairments tentatively linked to the hippocampus, a neurogenic region of the brain important in memory function and learning. Hippocampal neurogenesis is positively regulated by voluntary exercise, which is also known to improve hippocampal-dependent cognitive functions. In this work, we irradiated the brains of C57/BL6 mice on postnatal day 9 and evaluated both the acute effects of irradiation and the effects of voluntary running on hippocampal neurogenesis and behavior 3 months after irradiation. Voluntary running significantly restored precursor cell and neurogenesis levels after a clinically relevant, moderate dose of irradiation. We also found that irradiation perturbed the structural integration of immature neurons in the hippocampus and that this was reversed by voluntary exercise. Furthermore, irradiation-induced behavior alterations observed in the open-field test were ameliorated. Together, these results clearly demonstrate the usefulness of physical exercise for functional and structural recovery from radiation-induced injury to the juvenile brain, and they suggest that exercise should be evaluated in rehabilitation therapy of childhood cancer survivors.